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molecular pharmaceutics

By the time you have accrued enough data to write a manuscript, you will likely want to publish as soon as possible. Rapid publication can accelerate the dissemination of findings, decrease the likelihood of being scooped, and allow a quicker return to the laboratory to work on the next study. Whether you are currently performing experiments or are in the midst of writing, the following Molecular Pharmaceutics - Review Speed data may help you to select an efficient and right journal for your manuscripts.

The average number of days from manuscript submission to the initial editorial decision on the article. If your manuscript is rejected by the editor without the peer-reviewed process, please share with the community how many days you got the rejection email from the editor's office. If your manuscript is sent to reviewers, please share with the community how many days the evaluated process took by editor's office not include the evaluated process of reviewers.

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Please share with the community how many days the entire process took by the editor's office. The average number of days between the date of manuscript submission and date of receiving the editorial acceptance decision.

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How many reviewers are in the entire revision process? The average number of external revision rounds during the entire peer-reviewed process include both accepted and rejected manuscript. How many rounds of external review did you go through? Ranking by Impact Factor. Ranking by Popularity. Register a FREE account. Academic Accelerator. Acceptance Rate. Impact Factor. Journal Profile. Research Hotspot. Review Speed. Molecular Pharmaceutics Review Speed.

Write a Review See All Reviews. Submission To 1 st Editorial Decision 7. Share Your Experiences. Submission To 1 st Revision Report - days. Submission To Acceptance - days.Alzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50 years.

Consequently, the development of treatments that slow or halt the disease progression have become imperative to both improve the quality of life for patients as well as reduce the health care costs attributable to Alzheimer's disease. Currently, there are four FDA-approved drugs that treat the symptoms of Alzheimer's disease by inhibiting the active site of acetylcholinesterase AChEthe enzyme responsible for the degradation of acetylcholine, thereby raising the levels of neurotransmitter in the synaptic cleft.

This grid box was designed to include regions of both the catalytic site and the peripheral anionic site. Otherwise, standard docking settings were used for the AutoDock calculations, as previously detailed. Prior to use, an aliquot of the gelatin solution was diluted in water. For the assay, the solution was diluted until enzyme activity between 0. Compounds were prepared as solutions in methanol.

The increase of absorbance at nm was monitored for 2 to 5 min. All assays were run in triplicate. Initial rates were determined by subtracting the average observed initial rate from the non-enzymatic reaction. The fluorescence emission spectrum was recorded between and nm, with excitation at nm.

The fluorescence intensities were averaged, and the average background fluorescence of buffer only, or buffer and THC, was subtracted. The corrected fluorescence values were plotted with their standard deviation. The student's t-test function of Microsoft Excel was used to determine p values and assess statistical significance between reactions. In fact, given the proximity of the PAS to the protein channel leading to the catalytic triad active site, it is possible to block substrate entry into the active site while bound to the PAS, thus preventing the formation of an ESI complex.

Thus, these studies verify our docking results and demonstrate that THC and propidium are mutually exclusive PAS inhibitors.

Pharmacoengineering and Molecular Pharmaceutics

The catalytic triad residues of AChE green and water molecules included in the docking calculations light blue spheres are shown. A Kinetic analysis of AChE inhibition by 0. It has been shown that ThT also can bind to the PAS and that this binding leads to an increase in fluorescence. Presumably, this phenomenon results from ThT serving as a molecular rotor in which fluorescence quantum yield is sensitive to the intrinsic rotational relaxation; thus, when molecular rotation is slowed by protein binding, the quantum yield of the molecule can increase dramatically.

In contrast to previous studies aimed at utilizing cannabinoids in Alzheimer's disease therapy, 8 - 10 our results provide a mechanism whereby the THC molecule can directly impact Alzheimer's disease pathology. We note that while THC provides an interesting Alzheimer's disease drug lead, it is a psychoactive compound with strong affinity for endogenous cannabinoid receptors.

molecular pharmaceutics

National Center for Biotechnology InformationU. Mol Pharm. Author manuscript; available in PMC Oct 6. Lisa M. Author information Copyright and License information Disclaimer. Corresponding author. Copyright notice. The publisher's final edited version of this article is available at Mol Pharm.

See other articles in PMC that cite the published article. Abstract Alzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50 years.Numerous and frequently-updated resource results are available from this WorldCat.

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molecular pharmaceutics

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From Molecule to Medicine

Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied. The E-mail Address es field is required. Please enter recipient e-mail address es.Molecular Pharmaceutics is a peer-reviewed scientific journal, published since by the American Chemical Society.

The current Editor is Gordon L. Molecular Pharmaceutics publishes the results of original research that contributes significantly to the molecular mechanistic understanding of drug delivery and drug delivery systems. The journal encourages contributions describing research at the interface of drug discovery and drug development.

Scientific areas within the scope of the journal include physical and pharmaceutical chemistry, biochemistry and biophysics, molecular and cellular biology, and polymer and materials science as they relate to drug and drug delivery system efficacy. Theoretical and experimental peer-reviewed communications, full-length research papers, brief articles, and critical reviews are welcomed.

Molecular Pharmaceutics and Drug Delivery

MP has an Impact Factor of 5. The proper. Cellular lipids are more efficient than proteins in trapping most drugs and hence reducing the free intracellular drug concentration. This is shown by researchers at Uppsala University in an article published in Molecular The most common type of lung cancer, non-small cell lung cancer NSCLCcontinues to be difficult to treat, with five year survival rates of about 36 percent for stage 3A tumors.

Jefferson College of Pharmacy researchers To treat headaches, back pain or fever, most of us have reached for ibuprofen at one point or another. But we often have to take doses every four to six hours if the pain warrants it. Now scientists are working on a way to In a recently accepted manuscript titled "Deep learning applications for predicting pharmacological properties of drugs and drug repurposing using transcriptomic data", scientists from Insilico Medicine, Inc located at the Optogenetics, which uses light to control cellular events, is poised to become an important technology in molecular biology and beyond.

Bone grafts, which are used to treat head injuries and birth defects, still pose major medical challenges, but scientists are reporting progress toward a new hormone therapy that could improve the outcomes of these surgeries. All too often, when a person takes a pill full of a potent and effective drug, the drug passes straight through the body, not reaching the organ where it is needed—a waste of money and inconvenient if it is a cold medicine, Patients treated with Herceptin, a monoclonal antibody that targets Some of these agents, such as tumor necrosis factor-alpha A Wayne State University researcher has successfully tested a technique that can lead to more effective use of nanoparticles as a drug delivery system.

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By using our site, you acknowledge that you have read and understand our Privacy Policy and Terms of Use. Home Journals Molecular Pharmaceutics Molecular Pharmaceutics is a peer-reviewed scientific journal, published since by the American Chemical Society. Molecular Pharmaceutics. Date 6 hours 12 hours 1 day 3 days all. Last day 1 week 1 month all. A lipid 'trap' inside cells reduces drug effectiveness Cellular lipids are more efficient than proteins in trapping most drugs and hence reducing the free intracellular drug concentration.

May 18, Nanoparticles for lung cancer pass next test The most common type of lung cancer, non-small cell lung cancer NSCLCcontinues to be difficult to treat, with five year survival rates of about 36 percent for stage 3A tumors. Apr 11, Longer-lasting pain relief with MOFs To treat headaches, back pain or fever, most of us have reached for ibuprofen at one point or another.

Apr 26, Deep learning applied to drug discovery and repurposing In a recently accepted manuscript titled "Deep learning applications for predicting pharmacological properties of drugs and drug repurposing using transcriptomic data", scientists from Insilico Medicine, Inc located at the Computer Sciences.

May 26, Team uses lasers to spatially and temporally control the release of a tagged protein inside a cell Optogenetics, which uses light to control cellular events, is poised to become an important technology in molecular biology and beyond. Jan 08, Numerous and frequently-updated resource results are available from this WorldCat. Please choose whether or not you want other users to be able to see on your profile that this library is a favorite of yours.

Finding libraries that hold this item You may have already requested this item. Please select Ok if you would like to proceed with this request anyway. All rights reserved. Privacy Policy Cookie Notice Terms and Conditions WorldCat is the world's largest library catalog, helping you find library materials online.

Don't have an account? Your Web browser is not enabled for JavaScript. Some features of WorldCat will not be available. Create lists, bibliographies and reviews: or. Search WorldCat Find items in libraries near you. Advanced Search Find a Library. Your list has reached the maximum number of items. Please create a new list with a new name; move some items to a new or existing list; or delete some items. Your request to send this item has been completed. APA 6th ed. Note: Citations are based on reference standards.

However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied.Molecular Pharmaceutics - Impact Factor. The Impact Factor of Molecular Pharmaceutics is 4. The Impact Factor IF or Journal Impact Factor JIF of an academic journal is a scientometric index that reflects the yearly average number of citations that recent articles published in a given journal received.

It is frequently used as a proxy for the relative importance of a journal within its field; journals with higher impact factors are often deemed to be more important than those with lower ones. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years Note that impact factors are reported in ; they cannot be calculated until all of the publications have been processed by the indexing agency.

In addition to the 2-year Impact Factor, the 3-year Impact Factor and 5-year Impact Factor can provide further insights into the impact of Molecular Pharmaceutics. Impact Factor Trend Prediction System provides an open, transparent, and straightforward platform to help academic researchers Predict future journal impact and performance through the wisdom of crowds.

Impact Factor Trend Prediction System displays the exact community-driven Data without secret algorithms, hidden factors, or systematic delay. An ISSN is an 8-digit code used to identify newspapers, journals, magazines and periodicals of all kinds and on all media—print and electronic.

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Molecular Pharmaceutics

Molecular Pharmaceutics - Publisher. The Publication History of Molecular Pharmaceutics covers ongoing. Molecular Pharmaceutics - Categories. Molecular Pharmaceutics is a peer-reviewed scientific journal.

molecular pharmaceutics

Molecular Pharmaceutics - Journal Metrics. It is impossible to get a true picture of impact using a single metric alone, so a basket of metrics is needed to support informed decisions. Ranking by Impact Factor. Ranking by Popularity. Academic Accelerator Impact Factor Database. Impact Factor Database Search Engine. Acceptance Rate. Impact Factor. Journal Profile. Research Hotspot. Review Speed. Molecular Pharmaceutics Impact Factor Cited Articles. Molecular Pharmaceutics Impact Factor Prediction Molecular Pharmaceutics Impact Factor Trend.

The chart clearly shows a downtrend of Impact Factor in Molecular Pharmaceutics Impact Factor History. Impact Factor 4. Molecular Pharmaceutics Article Volume Origin Article.Molecular Pharmaceutics.

Review this journal Show reviews. Journal info provided by editor. Disciplines: PharmaceuticsDrugs. Aims and scope The editor has not yet provided this information. Editor login. Latest review Outcome: Rejected im. Motivation: Although the paper I submitted was actually a direct response to a polemic attacking our own work quite personally, and published in the same journal, the response read " In other words they sought to block our side of the debate.

After I appealed and pointed out that one could not BE more specialised than the journal that had published the original paper, I got "your paper in it's sic present form is a review of a review and is not acceptable as a scholarly review or perspective".

In other words they do not want to hear criticisms of papers they have published if it does not suit their own views. I am utterly disgusted by them, and I would advise anyone to avoid submitting anything serious there. News Contact us Terms and conditions Privacy policy Visitor statistics scirev.


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